Podocytes undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy
نویسندگان
چکیده
منابع مشابه
The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy.
Podocytes are highly differentiated, postmitotic cells, whose function is largely based on their complex cytoarchitecture. The differentiation of podocytes coincides with progressive expression of maturity markers, including WT-1, CALLA, C3b receptor, GLEPP-1, podocalyxin, and synaptopodin. In collapsing forms of focal segmental glomerulosclerosis (FSGS), including idiopathic FSGS and HIV-assoc...
متن کاملCollapsing glomerulopathy associated with inherited mitochondrial injury.
Laura Barisoni1, Francesca Diomedi-Camassei2, Filippo M. Santorelli3, Gianluca Caridi4, David B. Thomas5, Francesco Emma6, Fiorella Piemonte7 and Gian Marco Ghiggeri4 1Department of Pathology and Medicine, New York University, New York, New York, USA; 2Division of Pathology, Department of Laboratory Medicine, Bambino Gesu` Children’s Hospital and Research Institute, Rome, Italy; 3Division of Mo...
متن کاملCollapsing glomerulopathy associated with pulmonary tuberculosis
Collapsing glomerulopathy (CG) usually presents with reduced glomerular filtration rate, heavy proteinuria and has unfavorable prognosis. Numerous associations with CG are found. We encountered a case of CG associated with pulmonary tuberculosis presenting with proteinuria and dialysis-requiring severe renal failure. Our patient made partial recovery of his renal function and became dialysis-in...
متن کاملAdult-onset Still's disease associated with collapsing glomerulopathy
A young woman of African descent presented with fevers, arthralgia, lymphadenopathy and a skin rash. Modest proteinuria was also noted. The clinical picture suggested an acute HIV sero-conversion illness, and a renal biopsy showed a collapsing glomerulopathy compatible with that diagnosis. However, HIV serology proved persistently negative and a diagnosis of Adult Still's disease was subsequent...
متن کاملAcute Epstein–Barr virus infection-associated collapsing glomerulopathy
A 21-year-old woman presenting with acute Epstein-Barr virus (EBV) infection (infectious mononucleosis) was noted to have renal involvement. She had proteinuria, leukocyturia and microscopic hematuria, and 10 days after admission became nephrotic (23 g of protein per g of creatinine). Renal biopsy revealed glomerular tuft collapse, visceral epithelial cell proliferation and vacuolization consis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.1998.00845.x